FRAT® (Folate Receptor Antibody Test) is a test to identify autoantibodies to the folate receptor (FRAA). It is a blood test used to check whether the body has antibodies that interfere with folate (vitamin B9) reaching the brain.
The brain needs folate to develop and function properly. For folate to enter the brain, it uses special "receptors" located on the blood-brain barrier.
In some individuals, the body produces autoantibodies against these receptors - meaning the immune system mistakenly attacks what is trying to bring folate to the brain.
When this occurs, the brain does not receive enough folate, even if blood levels are normal.
According to a guide for pediatricians from Children's Mercy (2025), the FRAT test is not mandatory before starting treatment with folinic acid, but it can help in assessing the likelihood of a response.
📊 Data:
- 58-76% of children with ASD will test positive for FRAA
- Children who are positive for FRAA are more likely to respond to treatment
🏥 Test Availability:
- The test is available in Israel through AMC laboratories in Rishon Lezion
- Cost: approximately 1,700 NIS
- Wait time for results: 4-6 weeks
💡 Bottom Line: If a family wishes to try treatment regardless of the test results, starting treatment with folinic acid without the test is a reasonable option. (According to the guide mentioned above)